Order Adult Movement Disorders Assignment

Order Adult Movement Disorders Assignment
Order Adult Movement Disorders Assignment
1. A 40-year-old man has a family history of
hereditary neurodegenerative disease and
early death. His father died of a rapidly progressive dementia at the age of 50 and he
has previously been told that he has the
defective gene. He presents with personality
change and non-purposeful, slow, rhythmic
movements of his hands and face. A magnetic
resonance imaging (MRI) indicates atrophy
in the head of the caudate nucleus. Which
one of the following neurotransmitter deficiencies is most likely to be responsible?
a. Dopamine in the substantia nigra
b. Substance P in the subthalamic nucleus
c. Acetylcholine and gamma-aminobutyric
acid in the striatum
d. Serotonin in the globus pallidus
e. Glutamate in the cortex
2. A 43-year-old man has a father who died
from Huntington’s disease. The son was
tested and found to have the gene for Huntington’s disease. Which one of the following
is true regarding the offspring of those with
Huntington’s disease?
a. All children are at risk only if the affected
parent is male
Order Adult Movement Disorders Assignment
b. 1 in 10 are at risk only if the affected
parent is female
c. 1 in 8 are at risk for the disease
d. 1 in 4 are at risk for the disease
e. 1 in 2 are at risk for the disease
3. Damage to the subthalamic nucleus is associated with which one of the following
a. Myoclonus
b. Dystonic tremor
c. Hemiballism
d. Levodopa-induced dyskinesia
e. Tardive dyskinesia
4. Tardive dyskinesia is most likely the result
of receptor changes causing hypersensitivity
to which one of the following neurotransmitters?
a. Serotonin (5-HT)
b. Acetylcholine
c. Enkephalin
d. Dopamine
5. Which one of the following statements
regarding dystonia is most accurate?
a. Isolated foot dystonia is very rare and may
suggest an underlying Parkinsonian disorder or brain structural abnormality
b. Torticollis is the least common dystonia
c. Segawa’s disease is a primary dystonia
responsive to antidopaminergic drugs
d. Trihexyphenidyl is the primary treatment
for drug-induced dystonia
e. Blepharospasm is involuntary opening of
eyelids resulting in paradoxical blinking
6. A 65-year-old man presents with difficulty
getting out of chairs and problems walking
over the last year with multiple falls. On
examination, his face appeared mask-like
with reduced blinking and slight drooling,
and he had a pill-rolling tremor at rest
bilaterally, and on passive movement demonstrated cogwheel rigidity. His handwriting
became smaller towards the end of a
sentence. There was no weakness, sensory
problems, or abnormalities in his reflexes.
There are no autonomic symptoms. He had
a stooped posture and walked with a slow
shuffling gait, with a noticeably reduced
arm swing. Which one of the following
statements regarding this condition is most
a. It may present with a 3 Hz rest pill
rolling tremor
b. The major neuronal loss is in the substantia nigra pars reticularis
c. It is associated with a fluent aphasia
d. Loss of smell is a non-motor symptom
of this disease
e. Dyskinesias are common in nonmedicated patients
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