Inhibitors of Bacterial Nucleic Acid Synthesis or Function

Inhibitors of Bacterial Nucleic Acid Synthesis or Function
Inhibitors of Bacterial Nucleic Acid Synthesis or Function
Directions for questions 1−3
Match each antibiotic drug w ith the appropriate description
(each lettered option can be selected once, m ore than once, or not
at all).
A. Cipro oxacin
B. Metronidazole
C. Sulfadiazine
D. Sulfam ethoxazole
E. Trim ethoprim
Di culty level: Easy
1. A prodrug that requires bacterial activation
Di culty level: Easy
2. This drug blocks the last two steps in bacterial tetrahydrofolate biosynthesis
Di culty level: Easy
3. Resistance to this drug m ay be due to a change in DNA
Di culty level: Easy
Inhibitors of Bacterial Nucleic Acid Synthesis or Function
4. An 83-year-old fem ale resident in a nursing facility presented
w ith fever (100.5°F, 38°C), dry cough, and general m alaise.
Further exam s led to the diagnosis of hospital-acquired pneum onia due to Pseudom onas aeruginosa. Treatm ent was started
w ith a drug that is e ective against m ost gram -negative bacteria, as well as against som e m ycobacteria, m ycoplasm as,
chlam ydiae, and rickettsiae. W hich of the follow ing drugs
was m ost likely given?
A. Piperacillin
B. Ceftazidim e
C. Cipro oxacin
D. Erythromycin
E. Vancomycin
416 Chemotherapeutic Drugs
Di culty level: Medium
5. A 53-year-old wom an su ering from a urinary tract infection
started a treatm ent w ith trim ethoprim -sulfam ethoxazole.
One week later, burning upon urination was still pronounced,
and the physician suspected that resistance to sulfam ethoxazole had occurred. This resistance was m ost likely due to
w hich of the follow ing m echanism s?
A. Increased perm eability of bacterial cell m em brane
B. Decreased sulfonam ide binding to bacterial ribosom es
C. Increased production of para-am inobenzoic acid
D. Decreased sulfonam ides binding to dihydrofolate reductase
E. Decreased activity of the m ultidrug e ux pum p
Di culty level: Medium
6. A 59-year-old m an com plained to his physician that his skin
itched all over his body. Two weeks earlier, he had begun oral
antibiotic therapy for acute pharyngitis. Physical exam ination
showed a di use m aculopapular rash. Which of the follow ing
drugs m ost likely caused the patient’s derm atitis?
A. Aztreonam
B. Piperacillin
C. Trim ethoprim -sulfam ethoxazole
D. Vancomycin
E. Gentam icin
Di culty level: Easy
7. A 50-year-old obese m an complained to his physician of a sharp
pain in his left calf. Medical history indicated that 1 week ago
he had started an antibiotic treatm ent for acute prostatitis.
Further exam s led to the diagnosis of Achilles tendon rupture.
Which of the follow ing drugs m ost likely led to the patient’s
leg pain?
Inhibitors of Bacterial Nucleic Acid Synthesis or Function
A. Am picillin
B. Doxycycline
C. Ceftriaxone
D. Erythromycin
E. Cipro oxacin
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