Buy Bacterial Cell Wall Synthesis Inhibitors

Buy Bacterial Cell Wall Synthesis Inhibitors
Buy Bacterial Cell Wall Synthesis Inhibitors
Questions 1−4
1. H
2. J
3. F
4. B
Learning objective: Explain the mechanism of action of β-lactam
antibiotics.
5. C Cephalosporins are β-lactam antibiotics. The m echanism
of action of all β-lactam antibiotics involves the inhibition of
transpeptidase, the enzym e that catalyzes the nal connection (cross-link) of two am ino sugar chains by peptide bridges.
In this way, the synthesis of peptidoglycans is inhibited.
A, B, D, E See correct answer explanation.
Learning objective: Describe the renal elimination of cephalosporins.
6. A Most com m unit y-acquired urinary tract infections are due
to Escherichia coli. First-, second-, and third-generation cephalosporin, uoroquinolones, and trim ethoprim -sulfam etoxazole
are rst-line agents for these infections. Most cephalosporins
are elim inated by the kidney, m ainly by active secretion in the
proxim al tubule (two notable exceptions are ceftriaxone and
cefoperazone, w hich are excreted m ainly through the biliary
tract). In m ost cases, concentrations in urine are higher than
those in plasm a.
B Macrolides are m ainly elim inated by biliary excretion.
C Metronidazole is m ainly elim inated by liver m etabolism .
D Am inoglycosides are excreted alm ost entirely by glom erular ltration only.
E Renal excretion of tetracyclines occurs by glom erular ltration and tubular reabsorption.
Learning objective: Identify the drug contraindicated in a patient
with previous allergic reaction to β-lactam drugs.
7. C The signs of the patient and the lab results strongly suggest
the diagnosis of gonorrhea. Ceftriaxone would be the rstline agent for gonorrhea, but a previous anaphylactic reaction
to penicillin contraindicates the use of m ost β-lactam drugs.
A, B, D, E All of these antibiotics are e ective against Neisseria gonorrhoeae; they are not rst-line agents, but none of
them are contraindicated in this case.
Learning objective: Identify the drug used to treat Neisseria
meningitidis.
8. B The patient’s sym ptom s and lab results indicate that she
was m ost likely su ering from m eningitis due to N. m eningitidis. In this disease, the preferred treatm ents are penicillin G
(4 m illion units intravenously every 4 hours) and a thirdgeneration cephalosporin (m ainly ceftriaxone).
A, C Although N. m eningitidis is sensitive to these antibiotics, a bactericidal drug m ust be given in serious infectious
diseases.
D, E These antibiotics are m ainly active against gram –
negative bacilli.
F N. m eningitidis is not sensitive to m etronidazole.
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